Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor

Bacterial tRNA-guanine transglycosylase (Tgt) catalyses the exchange of the genetically encoded guanine at the wobble position of tRNAs(His,Tyr,Asp,Asn) by the premodified base preQ(1), which is further converted to queuine at the tRNA level. As eucaryotes are not able to synthesise queuine de novo...

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Detalles Bibliográficos
Autores principales: Biela, Inna, Tidten-Luksch, Naomi, Immekus, Florian, Glinca, Serghei, Nguyen, Tran Xuan Phong, Gerber, Hans-Dieter, Heine, Andreas, Klebe, Gerhard, Reuter, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660597/
https://www.ncbi.nlm.nih.gov/pubmed/23704982
http://dx.doi.org/10.1371/journal.pone.0064240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660597/
https://www.ncbi.nlm.nih.gov/pubmed/23704982
http://dx.doi.org/10.1371/journal.pone.0064240

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