Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel

Pore-blocking toxins inhibit voltage-dependent K(+) channels (K(v) channels) by plugging the ion-conduction pathway. We have solved the crystal structure of paddle chimera, a K(v) channel in complex with charybdotoxin (CTX), a pore-blocking toxin. The toxin binds to the extracellular pore entryway w...

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Detalles Bibliográficos
Autores principales: Banerjee, Anirban, Lee, Alice, Campbell, Ernest, MacKinnon, Roderick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660741/
https://www.ncbi.nlm.nih.gov/pubmed/23705070
http://dx.doi.org/10.7554/eLife.00594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660741/
https://www.ncbi.nlm.nih.gov/pubmed/23705070
http://dx.doi.org/10.7554/eLife.00594

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