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Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel
Pore-blocking toxins inhibit voltage-dependent K(+) channels (K(v) channels) by plugging the ion-conduction pathway. We have solved the crystal structure of paddle chimera, a K(v) channel in complex with charybdotoxin (CTX), a pore-blocking toxin. The toxin binds to the extracellular pore entryway w...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660741/ https://www.ncbi.nlm.nih.gov/pubmed/23705070 http://dx.doi.org/10.7554/eLife.00594 |