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Identification of Stable Benzo[a]pyrene-7,8-dione-DNA Adducts in Human Lung Cells
[Image: see text] Metabolic activation of the proximate carcinogen benzo[a]pyrene-7,8-trans-dihydrodiol (B[a]P-7,8-trans-dihydrodiol) by aldo-keto reductases (AKRs) leads to B[a]P-7,8-dione that is both electrophilic and redox-active. B[a]P-7,8-dione generates reactive oxygen species resulting in ox...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660951/ https://www.ncbi.nlm.nih.gov/pubmed/23587017 http://dx.doi.org/10.1021/tx300476m |