Cargando…

Identification of Stable Benzo[a]pyrene-7,8-dione-DNA Adducts in Human Lung Cells

[Image: see text] Metabolic activation of the proximate carcinogen benzo[a]pyrene-7,8-trans-dihydrodiol (B[a]P-7,8-trans-dihydrodiol) by aldo-keto reductases (AKRs) leads to B[a]P-7,8-dione that is both electrophilic and redox-active. B[a]P-7,8-dione generates reactive oxygen species resulting in ox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Meng, Blair, Ian A., Penning, Trevor M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660951/ https://www.ncbi.nlm.nih.gov/pubmed/23587017 http://dx.doi.org/10.1021/tx300476m

Ejemplares similares

Interception of Benzo[a]pyrene-7,8-dione by UDP Glucuronosyltransferases (UGTs) in Human Lung Cells
por: Zhang, Li, et al.
Publicado: (2013)

Regulation of Benzo[a]pyrene-Mediated DNA- and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells
por: Gelhaus, Stacy L., et al.
Publicado: (2010)

Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts
por: Chary, Parvathi, et al.
Publicado: (2013)

Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs
por: Borska, Lenka, et al.
Publicado: (2014)

Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.
por: Stowers, S J, et al.
Publicado: (1985)

Benzo(a)pyrene diolepoxide-DNA adducts detected by synchronous fluorescence spectrophotometry.
por: Vahakangas, K, et al.
Publicado: (1985)

Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct
por: Jee, Seung-Cheol, et al.
Publicado: (2020)

Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study
por: Cherif, Lynda Saber, et al.
Publicado: (2021)

Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells.
por: Borm, P J, et al.
Publicado: (1997)

Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor
por: Shiizaki, Kazuhiro, et al.
Publicado: (2017)

In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay
por: Sipinen, V., et al.
Publicado: (2010)

Resveratrol inhibits benzo[a]pyrene–DNA adduct formation in human bronchial epithelial cells
por: Berge, G, et al.
Publicado: (2004)

Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland.
por: Wigley, C. B., et al.
Publicado: (1978)

Benzo[a]pyrene and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced locomotor and reproductive senescence and altered biochemical parameters of oxidative damage in Canton-S Drosophila melanogaster
por: Johnson, Titilayo Omolara, et al.
Publicado: (2021)

Analysis of 7,8-Dihydro-8-oxo-2′-deoxyguanosine in Cellular DNA during Oxidative Stress
por: Mangal, Dipti, et al.
Publicado: (2009)

Oxidative Damage to Nucleic Acids and Benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA Adducts and Chromosomal Aberration in Children with Psoriasis Repeatedly Exposed to Crude Coal Tar Ointment and UV Radiation
por: Borska, Lenka, et al.
Publicado: (2014)

Induction of Cell Death, DNA Strand Breaks, and Cell Cycle Arrest in DU145 Human Prostate Carcinoma Cell Line by Benzo[a]pyrene and Benzo[a]pyrene-7,8-diol-9,10-epoxide
por: Nwagbara, Onyinye, et al.
Publicado: (2007)

Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment.
por: Goldstein, L S, et al.
Publicado: (1998)

Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts
por: Zahin, Maryam, et al.
Publicado: (2014)

DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene
por: Gerhards, Martin, et al.
Publicado: (2022)

Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase
por: Reed, Lindsay, et al.
Publicado: (2020)

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Benzo[a]pyrene–DNA Adducts, and Genomic DNA Methylation in Cord Blood
por: Herbstman, Julie B., et al.
Publicado: (2012)

Food borne bacterial models for detection of benzo[a]pyrene‐DNA adducts formation using RAPD‐PCR
por: Lanzone, Valentina, et al.
Publicado: (2016)

Examination of adduct formation in vivo in the mouse between benzo(a)pyrene and DNA of skin and hemoglobin of red blood cells.
por: Shugart, L, et al.
Publicado: (1985)

DNA Polymerase Eta Participates in the Mutagenic Bypass of Adducts Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells
por: Klarer, Alden C., et al.
Publicado: (2012)

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ
por: Jha, Vikash, et al.
Publicado: (2016)

Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
por: Zhang, Yong, et al.
Publicado: (2019)

Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse
por: Lemieux, Christine L, et al.
Publicado: (2011)

Benzo [Image: see text] pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice
por: Zuo, Jie, et al.
Publicado: (2014)

Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line
por: Simon, Bridget R., et al.
Publicado: (2014)

Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene
por: Hamouchene, Hamza, et al.
Publicado: (2011)

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation
por: Sáenz, Diógenes Herreño, et al.
Publicado: (2007)

Interaction of benzo[a]pyrene diol epoxide isomers with human serum albumin: Site specific characterisation of adducts and associated kinetics
por: Motwani, Hitesh V., et al.
Publicado: (2016)

Bacillus subtilis is a Potential Degrader of Pyrene and Benzo[a]pyrene
por: Hunter, Rochelle D., et al.
Publicado: (2005)

NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1
por: Stiborová, Marie, et al.
Publicado: (2016)

Proceedings: Metabolites of benzo (A) pyrene (BP) which bind to DNA.
por: King, H. W., et al.
Publicado: (1975)

Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
por: Wang, Huizeng, et al.
Publicado: (2023)

Excited State Kinetics of Benzo[a]pyrene Is Affected by Oxygen and DNA
por: Han, Yunxia, et al.
Publicado: (2023)

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
por: Talhaoui, Ibtissam, et al.
Publicado: (2013)

Detection of Benzo[a]pyrene Diol Epoxide Adducts to Histidine and Lysine in Serum Albumin In Vivo by High-Resolution-Tandem Mass Spectrometry
por: Zurita, Javier, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r08nuhekhnv8jt09lodie61215