Mechanisms underlying restoration of hepatic insulin sensitivity with CB1 antagonism in the obese dog model

Visceral fat has long been associated with the development of insulin resistance. Although the mechanism is not well understood, it has been suggested that an increase in this fat depot results in an elevation in portal vein levels of free fatty acids and/or adipokines, adversely affecting hepatic glucose production. Overactivity of the endocannabinoid system is closely related to abdominal obesity and type 2 diabetes, suggesting CB(1) receptor antagonism may exert its beneficial effects by decreasing visceral fat mass. A recent study published from our laboratory explores the role of chronic CB(1) receptor antagonism and the longitudinal changes in insulin sensitivity and fat deposition in the canine model.