Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment

Radiotherapy sensitizes unresponsive tumors to the antineoplastic activity of antibodies that target the inhibitory receptor CTLA-4 on T cells. One molecular mechanism accounting for this therapeutic synergy is the induction of NKG2D ligands on irradiated tumor cells. The fact that NKG2D receptors m...

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Detalles Bibliográficos
Autores principales: Demaria, Sandra, Pilones, Karsten A., Formenti, Silvia C., Dustin, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661148/
https://www.ncbi.nlm.nih.gov/pubmed/23802063
http://dx.doi.org/10.4161/onci.23127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661148/
https://www.ncbi.nlm.nih.gov/pubmed/23802063
http://dx.doi.org/10.4161/onci.23127

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