A new strategy to target regulatory T cells in solid tumors

The depletion of regulatory T cells (Tregs) is a promising therapeutic strategy to enhance antitumor immune responses. Our recent findings indicate that low doses of arsenic trioxide can delay tumor growth in murine models of colon and breast cancer by depleting Tregs through oxidative and nitrosati...

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Autores principales: Thomas-Schoemann, Audrey, Batteux, Frédéric, Alexandre, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661163/
https://www.ncbi.nlm.nih.gov/pubmed/23802078
http://dx.doi.org/10.4161/onci.23338
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author Thomas-Schoemann, Audrey
Batteux, Frédéric
Alexandre, Jérôme
author_facet Thomas-Schoemann, Audrey
Batteux, Frédéric
Alexandre, Jérôme
author_sort Thomas-Schoemann, Audrey
collection PubMed
description The depletion of regulatory T cells (Tregs) is a promising therapeutic strategy to enhance antitumor immune responses. Our recent findings indicate that low doses of arsenic trioxide can delay tumor growth in murine models of colon and breast cancer by depleting Tregs through oxidative and nitrosative bursts.
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spelling pubmed-36611632013-06-25 A new strategy to target regulatory T cells in solid tumors Thomas-Schoemann, Audrey Batteux, Frédéric Alexandre, Jérôme Oncoimmunology Author's View The depletion of regulatory T cells (Tregs) is a promising therapeutic strategy to enhance antitumor immune responses. Our recent findings indicate that low doses of arsenic trioxide can delay tumor growth in murine models of colon and breast cancer by depleting Tregs through oxidative and nitrosative bursts. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661163/ /pubmed/23802078 http://dx.doi.org/10.4161/onci.23338 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Thomas-Schoemann, Audrey
Batteux, Frédéric
Alexandre, Jérôme
A new strategy to target regulatory T cells in solid tumors
title A new strategy to target regulatory T cells in solid tumors
title_full A new strategy to target regulatory T cells in solid tumors
title_fullStr A new strategy to target regulatory T cells in solid tumors
title_full_unstemmed A new strategy to target regulatory T cells in solid tumors
title_short A new strategy to target regulatory T cells in solid tumors
title_sort new strategy to target regulatory t cells in solid tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661163/
https://www.ncbi.nlm.nih.gov/pubmed/23802078
http://dx.doi.org/10.4161/onci.23338
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