Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells

The specific 26S proteasome inhibitor bortezomib (BZ) potently induces autophagy, endoplasmic reticulum (ER) stress and apoptosis in multiple myeloma (MM) cell lines (U266, IM-9 and RPMI8226). The macrolide antibiotics including concanamycin A, erythromycin (EM), clarithromycin (CAM) and azithromyci...

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Detalles Bibliográficos
Autores principales: MORIYA, SHOTA, CHE, XIAO-FANG, KOMATSU, SEIICHIRO, ABE, AKIHISA, KAWAGUCHI, TOMOHIRO, GOTOH, AKIHIKO, INAZU, MASATO, TOMODA, AKIO, MIYAZAWA, KEISUKE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661227/
https://www.ncbi.nlm.nih.gov/pubmed/23546223
http://dx.doi.org/10.3892/ijo.2013.1870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661227/
https://www.ncbi.nlm.nih.gov/pubmed/23546223
http://dx.doi.org/10.3892/ijo.2013.1870

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