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Detecting negative selection on recurrent mutations using gene genealogy

BACKGROUND: Whether or not a mutant allele in a population is under selection is an important issue in population genetics, and various neutrality tests have been invented so far to detect selection. However, detection of negative selection has been notoriously difficult, partly because negatively s...

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Detalles Bibliográficos
Autores principales: Ezawa, Kiyoshi, Landan, Giddy, Graur, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661350/
https://www.ncbi.nlm.nih.gov/pubmed/23651527
http://dx.doi.org/10.1186/1471-2156-14-37