Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations

OBJECTIVES: Variants of the secreted glycoprotein, proprotein convertase subtilisin/kexin 9 (PCSK9), associate with both hypo- and hyper-cholesterolemic phenotypes. Herein, we carried out full exonic sequencing of PCSK9 documenting the frequency of single and multiple PCSK9 variations and their effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Mayne, Janice, Ooi, Teik Chye, Raymond, Angela, Cousins, Marion, Bernier, Lise, Dewpura, Thilina, Sirois, Francine, Mbikay, Majambu, Davignon, Jean, Chrétien, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661383/
https://www.ncbi.nlm.nih.gov/pubmed/23663650
http://dx.doi.org/10.1186/1476-511X-12-70

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661383/
https://www.ncbi.nlm.nih.gov/pubmed/23663650
http://dx.doi.org/10.1186/1476-511X-12-70

Ejemplares similares