Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle

The actin cytoskeleton–regulating GTPase Rac1 is required for insulin-stimulated GLUT4 translocation in cultured muscle cells. However, involvement of Rac1 and its downstream signaling in glucose transport in insulin-sensitive and insulin-resistant mature skeletal muscle has not previously been inve...

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Detalles Bibliográficos
Autores principales: Sylow, Lykke, Jensen, Thomas E., Kleinert, Maximilian, Højlund, Kurt, Kiens, Bente, Wojtaszewski, Jørgen, Prats, Clara, Schjerling, Peter, Richter, Erik A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661612/
https://www.ncbi.nlm.nih.gov/pubmed/23423567
http://dx.doi.org/10.2337/db12-1148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661612/
https://www.ncbi.nlm.nih.gov/pubmed/23423567
http://dx.doi.org/10.2337/db12-1148

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