Cargando…

Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes

Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against dia...

Descripción completa

Detalles Bibliográficos
Autores principales: Castellano, Jose M., Guinda, Angeles, Delgado, Teresa, Rada, Mirela, Cayuela, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661625/
https://www.ncbi.nlm.nih.gov/pubmed/23704520
http://dx.doi.org/10.2337/db12-1215
_version_ 1782270715847770112
author Castellano, Jose M.
Guinda, Angeles
Delgado, Teresa
Rada, Mirela
Cayuela, Jose A.
author_facet Castellano, Jose M.
Guinda, Angeles
Delgado, Teresa
Rada, Mirela
Cayuela, Jose A.
author_sort Castellano, Jose M.
collection PubMed
description Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against diabetes and metabolic syndrome. It improves insulin response, preserves functionality and survival of β-cells, and protects against diabetes complications. OA may directly modulate enzymes connected to insulin biosynthesis, secretion, and signaling. However, its major contributions appear to be derived from the interaction with important transduction pathways, and many of its effects are consistently related to activation of the transcription factor Nrf2. Doing that, OA induces the expression of antioxidant enzymes and phase II response genes, blocks NF-κB, and represses the polyol pathway, AGEs production, and hyperlipidemia. The management of type 2 diabetes requires an integrated approach, which includes the early intervention to prevent or delay the disease progression, and the use of therapies to control glycemia and lipidemia in its late stages. In this sense, the use of functional foods or drugs containing OA is, undoubtedly, an interesting path.
format Online
Article
Text
id pubmed-3661625
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-36616252014-06-01 Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes Castellano, Jose M. Guinda, Angeles Delgado, Teresa Rada, Mirela Cayuela, Jose A. Diabetes Perspectives in Diabetes Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against diabetes and metabolic syndrome. It improves insulin response, preserves functionality and survival of β-cells, and protects against diabetes complications. OA may directly modulate enzymes connected to insulin biosynthesis, secretion, and signaling. However, its major contributions appear to be derived from the interaction with important transduction pathways, and many of its effects are consistently related to activation of the transcription factor Nrf2. Doing that, OA induces the expression of antioxidant enzymes and phase II response genes, blocks NF-κB, and represses the polyol pathway, AGEs production, and hyperlipidemia. The management of type 2 diabetes requires an integrated approach, which includes the early intervention to prevent or delay the disease progression, and the use of therapies to control glycemia and lipidemia in its late stages. In this sense, the use of functional foods or drugs containing OA is, undoubtedly, an interesting path. American Diabetes Association 2013-06 2013-05-17 /pmc/articles/PMC3661625/ /pubmed/23704520 http://dx.doi.org/10.2337/db12-1215 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Perspectives in Diabetes
Castellano, Jose M.
Guinda, Angeles
Delgado, Teresa
Rada, Mirela
Cayuela, Jose A.
Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
title Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
title_full Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
title_fullStr Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
title_full_unstemmed Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
title_short Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
title_sort biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes
topic Perspectives in Diabetes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661625/
https://www.ncbi.nlm.nih.gov/pubmed/23704520
http://dx.doi.org/10.2337/db12-1215
work_keys_str_mv AT castellanojosem biochemicalbasisoftheantidiabeticactivityofoleanolicacidandrelatedpentacyclictriterpenes
AT guindaangeles biochemicalbasisoftheantidiabeticactivityofoleanolicacidandrelatedpentacyclictriterpenes
AT delgadoteresa biochemicalbasisoftheantidiabeticactivityofoleanolicacidandrelatedpentacyclictriterpenes
AT radamirela biochemicalbasisoftheantidiabeticactivityofoleanolicacidandrelatedpentacyclictriterpenes
AT cayuelajosea biochemicalbasisoftheantidiabeticactivityofoleanolicacidandrelatedpentacyclictriterpenes