The Type 2 Diabetes–Associated Gene Ide Is Required for Insulin Secretion and Suppression of α-Synuclein Levels in β-Cells

Genome-wide association studies have identified several type 2 diabetes (T2D) risk loci linked to impaired β-cell function. The identity and function of the causal genes in these susceptibility loci remain, however, elusive. The HHEX/IDE T2D locus is associated with decreased insulin secretion in re...

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Detalles Bibliográficos
Autores principales: Steneberg, Pär, Bernardo, Lisandro, Edfalk, Sara, Lundberg, Lisa, Backlund, Fredrik, Östenson, Claes-Göran, Edlund, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661649/
https://www.ncbi.nlm.nih.gov/pubmed/23349488
http://dx.doi.org/10.2337/db12-1045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661649/
https://www.ncbi.nlm.nih.gov/pubmed/23349488
http://dx.doi.org/10.2337/db12-1045

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