Disulfide-Bond Scanning Reveals Assembly State and β-Strand Tilt Angle of PFO β-Barrel

Perfringolysin O (PFO), a bacterial cholesterol-dependent cytolysin, binds to a mammalian cell membrane, oligomerizes into a circular prepore complex (PPC), and forms a 250-Å transmembrane β-barrel pore in the cell membrane. Each PFO monomer has two sets of 3 short α-helices that unfold and ultimate...

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Detalles Bibliográficos
Autores principales: Sato, Takehiro K., Tweten, Rodney K., Johnson, Arthur E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661704/
https://www.ncbi.nlm.nih.gov/pubmed/23563525
http://dx.doi.org/10.1038/nchembio.1228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661704/
https://www.ncbi.nlm.nih.gov/pubmed/23563525
http://dx.doi.org/10.1038/nchembio.1228

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