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Disulfide-Bond Scanning Reveals Assembly State and β-Strand Tilt Angle of PFO β-Barrel

Perfringolysin O (PFO), a bacterial cholesterol-dependent cytolysin, binds to a mammalian cell membrane, oligomerizes into a circular prepore complex (PPC), and forms a 250-Å transmembrane β-barrel pore in the cell membrane. Each PFO monomer has two sets of 3 short α-helices that unfold and ultimate...

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Detalles Bibliográficos
Autores principales:	Sato, Takehiro K., Tweten, Rodney K., Johnson, Arthur E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661704/ https://www.ncbi.nlm.nih.gov/pubmed/23563525 http://dx.doi.org/10.1038/nchembio.1228

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