Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold

PreQ(1) riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ(1) during biosynthesis of the essential tRNA base queuosine. We report the first preQ(1)-II riboswitch structure at 2.3 Å resolution, which uses a novel fold to achieve effector recognition at the confluence of a...

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Detalles Bibliográficos
Autores principales: Liberman, Joseph A., Salim, Mohammad, Krucinska, Jolanta, Wedekind, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661761/
https://www.ncbi.nlm.nih.gov/pubmed/23584677
http://dx.doi.org/10.1038/nchembio.1231
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author Liberman, Joseph A.
Salim, Mohammad
Krucinska, Jolanta
Wedekind, Joseph E.
author_facet Liberman, Joseph A.
Salim, Mohammad
Krucinska, Jolanta
Wedekind, Joseph E.
author_sort Liberman, Joseph A.
collection PubMed
description PreQ(1) riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ(1) during biosynthesis of the essential tRNA base queuosine. We report the first preQ(1)-II riboswitch structure at 2.3 Å resolution, which uses a novel fold to achieve effector recognition at the confluence of a three-way-helical junction flanking a pseudoknotted ribosome-binding site (RBS). The results account for preQ(1)-II-riboswitch-mediated translational control, and expand the known repertoire of ligand binding modes utilized by regulatory RNAs.
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spelling pubmed-36617612013-12-01 Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold Liberman, Joseph A. Salim, Mohammad Krucinska, Jolanta Wedekind, Joseph E. Nat Chem Biol Article PreQ(1) riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ(1) during biosynthesis of the essential tRNA base queuosine. We report the first preQ(1)-II riboswitch structure at 2.3 Å resolution, which uses a novel fold to achieve effector recognition at the confluence of a three-way-helical junction flanking a pseudoknotted ribosome-binding site (RBS). The results account for preQ(1)-II-riboswitch-mediated translational control, and expand the known repertoire of ligand binding modes utilized by regulatory RNAs. 2013-04-14 2013-06 /pmc/articles/PMC3661761/ /pubmed/23584677 http://dx.doi.org/10.1038/nchembio.1231 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Liberman, Joseph A.
Salim, Mohammad
Krucinska, Jolanta
Wedekind, Joseph E.
Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold
title Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold
title_full Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold
title_fullStr Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold
title_full_unstemmed Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold
title_short Structure of a class II preQ(1) riboswitch reveals ligand recognition by a new fold
title_sort structure of a class ii preq(1) riboswitch reveals ligand recognition by a new fold
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661761/
https://www.ncbi.nlm.nih.gov/pubmed/23584677
http://dx.doi.org/10.1038/nchembio.1231
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