An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids

An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.

Detalles Bibliográficos
Autores principales: Tsatsaroni, Alexandra, Zoidis, Grigoris, Zoumpoulakis, Panagiotis, Tsotinis, Andrew, Taylor, Martin C., Kelly, John M., Fytas, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661977/
https://www.ncbi.nlm.nih.gov/pubmed/23794760
http://dx.doi.org/10.1016/j.tetlet.2013.03.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661977/
https://www.ncbi.nlm.nih.gov/pubmed/23794760
http://dx.doi.org/10.1016/j.tetlet.2013.03.128

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