An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids

An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.

Detalles Bibliográficos
Autores principales: Tsatsaroni, Alexandra, Zoidis, Grigoris, Zoumpoulakis, Panagiotis, Tsotinis, Andrew, Taylor, Martin C., Kelly, John M., Fytas, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661977/
https://www.ncbi.nlm.nih.gov/pubmed/23794760
http://dx.doi.org/10.1016/j.tetlet.2013.03.128
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author Tsatsaroni, Alexandra
Zoidis, Grigoris
Zoumpoulakis, Panagiotis
Tsotinis, Andrew
Taylor, Martin C.
Kelly, John M.
Fytas, George
author_facet Tsatsaroni, Alexandra
Zoidis, Grigoris
Zoumpoulakis, Panagiotis
Tsotinis, Andrew
Taylor, Martin C.
Kelly, John M.
Fytas, George
author_sort Tsatsaroni, Alexandra
collection PubMed
description An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented.
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spelling pubmed-36619772013-06-19 An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids Tsatsaroni, Alexandra Zoidis, Grigoris Zoumpoulakis, Panagiotis Tsotinis, Andrew Taylor, Martin C. Kelly, John M. Fytas, George Tetrahedron Lett Article An explanation for the vast difference observed in the trypanocidal activity between the new secondary (N-methylated) hydroxamic acids 5 and 6, and their primary (nonmethylated) congeners 1a and 2, based on their E/Z conformational behaviour in DMSO, is presented. Elsevier 2013-06-19 /pmc/articles/PMC3661977/ /pubmed/23794760 http://dx.doi.org/10.1016/j.tetlet.2013.03.128 Text en © 2013 Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Tsatsaroni, Alexandra
Zoidis, Grigoris
Zoumpoulakis, Panagiotis
Tsotinis, Andrew
Taylor, Martin C.
Kelly, John M.
Fytas, George
An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
title An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
title_full An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
title_fullStr An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
title_full_unstemmed An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
title_short An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
title_sort e/z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661977/
https://www.ncbi.nlm.nih.gov/pubmed/23794760
http://dx.doi.org/10.1016/j.tetlet.2013.03.128
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