Minimizing the Maximum Expected Sample Size in Two-Stage Phase II Clinical Trials with Continuous Outcomes

Two-stage designs are commonly used for Phase II trials. Optimal two-stage designs have the lowest expected sample size for a specific treatment effect, for example, the null value, but can perform poorly if the true treatment effect differs. Here we introduce a design for continuous treatment respo...

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Detalles Bibliográficos
Autores principales: Wason, James M. S., Mander, Adrian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662082/
https://www.ncbi.nlm.nih.gov/pubmed/22651118
http://dx.doi.org/10.1080/10543406.2010.528104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662082/
https://www.ncbi.nlm.nih.gov/pubmed/22651118
http://dx.doi.org/10.1080/10543406.2010.528104

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