Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells

We found that basal-like breast cancer (BLBC) cells use Cdc42 to inhibit function of the redox/Fyn/c-Cbl (RFC) pathway, which normally functions to convert small increases in oxidative status into enhanced degradation of c-Cbl target proteins. Restoration of RFC pathway function by genetic or pharma...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hsing-Yu, Yang, Yin M, Stevens, Brett M, Noble, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662315/
https://www.ncbi.nlm.nih.gov/pubmed/23606532
http://dx.doi.org/10.1002/emmm.201202140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662315/
https://www.ncbi.nlm.nih.gov/pubmed/23606532
http://dx.doi.org/10.1002/emmm.201202140

Ejemplares similares