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Depletion of PAK1 enhances Ubiquitin-mediated Survivin degradation in pancreatic β-cells
Functional β-cell mass deficiency in diabetes results from imbalanced β-cell death and replication, and decreased PAK1 protein levels in human islets from donors with type 2 diabetes implicates a possible role for PAK1 in maintaining β-cell mass. Here, we aim to address the linkage between PAK1 and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662379/ https://www.ncbi.nlm.nih.gov/pubmed/23514967 http://dx.doi.org/10.4161/isl.24029 |