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A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems

BACKGROUND: α-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, (13)C and (1)H NMR as well as UV–vis spectroscopy. The α-mangostin dispersion in colloidal systems was...

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Autores principales: Ahmad, Madihah, Yamin, Bohari M, Mat Lazim, Azwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662622/
https://www.ncbi.nlm.nih.gov/pubmed/23680098
http://dx.doi.org/10.1186/1752-153X-7-85
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author Ahmad, Madihah
Yamin, Bohari M
Mat Lazim, Azwan
author_facet Ahmad, Madihah
Yamin, Bohari M
Mat Lazim, Azwan
author_sort Ahmad, Madihah
collection PubMed
description BACKGROUND: α-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, (13)C and (1)H NMR as well as UV–vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH. RESULT: The DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6. CONCLUSION: This research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template.
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spelling pubmed-36626222013-05-24 A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems Ahmad, Madihah Yamin, Bohari M Mat Lazim, Azwan Chem Cent J Research Article BACKGROUND: α-Mangostin was extracted with methanol from the rind of mangosteen fruit and purified by using silica gel column chromatography technique. The compound is characterised using infrared, (13)C and (1)H NMR as well as UV–vis spectroscopy. The α-mangostin dispersion in colloidal systems was studied by incorporating it with an ionic microgel, poly (N-Isopropylacrylamide)-co-2VP at different pH. RESULT: The DLS result showed the size of microgel-α-mangostin mixture declined from 548 nm to 200 nm upon the increment of the pH. Moreover, it was found the morphology of loaded compound depended largely on the nature of the continuous phase of the microgel system. Interestingly, by manipulating the pH, α-mangostin tends to form crystal at extremely low pH and transforms into spherical shapes at pH 6. CONCLUSION: This research shows different structures of the α-mangostin particle that are attributed by adjusting the pH using microgel systems as a template. BioMed Central 2013-05-16 /pmc/articles/PMC3662622/ /pubmed/23680098 http://dx.doi.org/10.1186/1752-153X-7-85 Text en Copyright © 2013 Ahmad et al.; licensee Chemistry Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ahmad, Madihah
Yamin, Bohari M
Mat Lazim, Azwan
A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems
title A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems
title_full A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems
title_fullStr A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems
title_full_unstemmed A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems
title_short A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems
title_sort study on dispersion and characterisation of α-mangostin loaded ph sensitive microgel systems
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662622/
https://www.ncbi.nlm.nih.gov/pubmed/23680098
http://dx.doi.org/10.1186/1752-153X-7-85
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