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Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression

Mouse Ikbkap gene encodes IKAP—one of the core subunits of Elongator—and is thought to be involved in transcription. However, the biological function of IKAP, particularly within the context of an animal model, remains poorly characterized. We used a loss-of-function approach in mice to demonstrate...

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Detalles Bibliográficos
Autores principales: Lin, Fu-Jung, Shen, Li, Jang, Chuan-Wei, Falnes, Pål Ø., Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662645/
https://www.ncbi.nlm.nih.gov/pubmed/23717213
http://dx.doi.org/10.1371/journal.pgen.1003516