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BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR
Protein-protein interactions represent difficult but increasingly important targets for the design of therapeutic compounds able to interfere with biological processes. Recently, fragment-based strategies have been proposed as attractive approaches for the elaboration of protein-protein surface inhi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662666/ https://www.ncbi.nlm.nih.gov/pubmed/23717610 http://dx.doi.org/10.1371/journal.pone.0064400 |