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Calculation of substrate binding affinities for a bacterial GH78 rhamnosidase through molecular dynamics simulations
Ram2 from Pediococcus acidilactici is a rhamnosidase from the glycoside hydrolase family 78. It shows remarkable selectivity for rutinose rather than para-nitrophenyl-alpha-l-rhamnopyranoside (p-NPR). Molecular dynamics simulations were performed using a homology model of this enzyme, in complex wit...
Autores principales: | Grandits, Melanie, Michlmayr, Herbert, Sygmund, Christoph, Oostenbrink, Chris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663046/ https://www.ncbi.nlm.nih.gov/pubmed/23914137 http://dx.doi.org/10.1016/j.molcatb.2013.03.012 |
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