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Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications

The ability to deliver drug molecules effectively across the blood–brain barrier into the brain is important in the development of central nervous system (CNS) therapies. Cerebral microdialysis is the only existing technique for sampling molecules from the brain extracellular fluid (ECF; also termed...

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Detalles Bibliográficos
Autores principales: Shannon, Richard J., Carpenter, Keri L. H., Guilfoyle, Mathew R., Helmy, Adel, Hutchinson, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663257/
https://www.ncbi.nlm.nih.gov/pubmed/23468415
http://dx.doi.org/10.1007/s10928-013-9306-4