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Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications
The ability to deliver drug molecules effectively across the blood–brain barrier into the brain is important in the development of central nervous system (CNS) therapies. Cerebral microdialysis is the only existing technique for sampling molecules from the brain extracellular fluid (ECF; also termed...
Autores principales: | Shannon, Richard J., Carpenter, Keri L. H., Guilfoyle, Mathew R., Helmy, Adel, Hutchinson, Peter J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663257/ https://www.ncbi.nlm.nih.gov/pubmed/23468415 http://dx.doi.org/10.1007/s10928-013-9306-4 |
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