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New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels
Selective blockers of the N-type voltage-sensitive calcium (Ca(V)) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type Ca(V) channel blocker, SO-3, are reviewed. SO-3 is a 25- amino acid conopeptide originally derived from...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663411/ |
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author | Wen, Lei Yang, Sheng Zhou, Wenxia Zhang, Yongxiang Huang, Peitang |
author_facet | Wen, Lei Yang, Sheng Zhou, Wenxia Zhang, Yongxiang Huang, Peitang |
author_sort | Wen, Lei |
collection | PubMed |
description | Selective blockers of the N-type voltage-sensitive calcium (Ca(V)) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type Ca(V) channel blocker, SO-3, are reviewed. SO-3 is a 25- amino acid conopeptide originally derived from the venom of Conus striatus, and contains the same 4-loop, 6-cysteine framework (C-C-CC-C-C) as O-superfamily conotoxins. The synthetic SO-3 has high analgesic activity similar to ω-conotoxin MVIIA (MVIIA), a selective N-type Ca(V) channel blocker approved in the USA and Europe for the alleviation of persistent pain states. In electrophysiological studies, SO-3 shows more selectivity towards the N-type Ca(V) channels than MVIIA. The dissimilarity between SO-3 and MVIIA in the primary and tertiary structures is further discussed in an attempt to illustrate the difference in selectivity of SO-3 and MVIIA towards N-type Ca(V) channels. |
format | Online Article Text |
id | pubmed-3663411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-36634112013-05-28 New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels Wen, Lei Yang, Sheng Zhou, Wenxia Zhang, Yongxiang Huang, Peitang Mar Drugs Review Selective blockers of the N-type voltage-sensitive calcium (Ca(V)) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type Ca(V) channel blocker, SO-3, are reviewed. SO-3 is a 25- amino acid conopeptide originally derived from the venom of Conus striatus, and contains the same 4-loop, 6-cysteine framework (C-C-CC-C-C) as O-superfamily conotoxins. The synthetic SO-3 has high analgesic activity similar to ω-conotoxin MVIIA (MVIIA), a selective N-type Ca(V) channel blocker approved in the USA and Europe for the alleviation of persistent pain states. In electrophysiological studies, SO-3 shows more selectivity towards the N-type Ca(V) channels than MVIIA. The dissimilarity between SO-3 and MVIIA in the primary and tertiary structures is further discussed in an attempt to illustrate the difference in selectivity of SO-3 and MVIIA towards N-type Ca(V) channels. Molecular Diversity Preservation International (MDPI) 2006-04-06 /pmc/articles/PMC3663411/ Text en © 2006 by MDPI Reproduction is permitted for noncommercial purposes. |
spellingShingle | Review Wen, Lei Yang, Sheng Zhou, Wenxia Zhang, Yongxiang Huang, Peitang New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels |
title | New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels |
title_full | New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels |
title_fullStr | New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels |
title_full_unstemmed | New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels |
title_short | New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels |
title_sort | new conotoxin so-3 targeting n-type voltage-sensitive calcium channels |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663411/ |
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