Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

Polyamine biosynthesis is a key drug target in African trypanosomes. The “resurrection drug” eflornithine (difluoromethylornithine), which is used clinically to treat human African trypanosomiasis, inhibits the first step in polyamine (spermidine) biosynthesis, a highly regulated pathway in most euk...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Suong, Jones, Deuan C., Wyllie, Susan, Fairlamb, Alan H., Phillips, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663545/
https://www.ncbi.nlm.nih.gov/pubmed/23525104
http://dx.doi.org/10.1074/jbc.M113.461137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663545/
https://www.ncbi.nlm.nih.gov/pubmed/23525104
http://dx.doi.org/10.1074/jbc.M113.461137

Ejemplares similares