Cargando…

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

Polyamine biosynthesis is a key drug target in African trypanosomes. The “resurrection drug” eflornithine (difluoromethylornithine), which is used clinically to treat human African trypanosomiasis, inhibits the first step in polyamine (spermidine) biosynthesis, a highly regulated pathway in most euk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Suong, Jones, Deuan C., Wyllie, Susan, Fairlamb, Alan H., Phillips, Margaret A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663545/ https://www.ncbi.nlm.nih.gov/pubmed/23525104 http://dx.doi.org/10.1074/jbc.M113.461137

Ejemplares similares

Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major
por: Ong, Han B., et al.
Publicado: (2011)

New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase
por: Tanaka, Yuta, et al.
Publicado: (2020)

Investigation of an Allosteric Deoxyhypusine Synthase Inhibitor in P. falciparum
por: Aroonsri, Aiyada, et al.
Publicado: (2022)

The Catalytic Architecture of Leukotriene C(4) Synthase with Two Arginine Residues
por: Saino, Hiromichi, et al.
Publicado: (2011)

Arginine 104 Is a Key Catalytic Residue in Leukotriene C(4) Synthase
por: Rinaldo-Matthis, Agnes, et al.
Publicado: (2010)

Structure and Mechanism of Human UDP-xylose Synthase: EVIDENCE FOR A PROMOTING ROLE OF SUGAR RING DISTORTION IN A THREE-STEP CATALYTIC CONVERSION OF UDP-GLUCURONIC ACID
por: Eixelsberger, Thomas, et al.
Publicado: (2012)

Inverted stereocontrol of iridoid synthase in snapdragon
por: Kries, Hajo, et al.
Publicado: (2017)

Diversified amino acid-mediated allosteric regulation of phosphoglycerate dehydrogenase for serine biosynthesis in land plants
por: Okamura, Eiji, et al.
Publicado: (2021)

Energy Landscapes and Catalysis in Nitric-oxide Synthase
por: Sobolewska-Stawiarz, Anna, et al.
Publicado: (2014)

The Allosteric Role of the AAA(+) Domain of ChlD Protein from the Magnesium Chelatase of Synechocystis Species PCC 6803
por: Adams, Nathan B. P., et al.
Publicado: (2013)

trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication
por: Zeymer, Cathleen, et al.
Publicado: (2014)

Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)
por: Miazzi, Cristina, et al.
Publicado: (2014)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

The Contribution of Non-catalytic Carbohydrate Binding Modules to the Activity of Lytic Polysaccharide Monooxygenases
por: Crouch, Lucy I., et al.
Publicado: (2016)

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT(JE)
por: Matthews, Sarah, et al.
Publicado: (2017)

Dissecting the Catalytic Mechanism of Trypanosoma brucei Trypanothione Synthetase by Kinetic Analysis and Computational Modeling
por: Leroux, Alejandro E., et al.
Publicado: (2013)

Self-assembly Is Prerequisite for Catalysis of Fe(II) Oxidation by Catalytically Active Subunits of Ferritin
por: Ebrahimi, Kourosh Honarmand, et al.
Publicado: (2015)

The N-terminus of Paenibacillus larvae C3larvinA modulates catalytic efficiency
por: Turner, Madison, et al.
Publicado: (2021)

Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2
por: Trostchansky, Andrés, et al.
Publicado: (2011)

Domain architecture divergence leads to functional divergence in binding and catalytic domains of bacterial and fungal cellobiohydrolases
por: Nakamura, Akihiko, et al.
Publicado: (2020)

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy
por: Yosef, Gal, et al.
Publicado: (2021)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling
por: Crabtree, Mark J., et al.
Publicado: (2013)

Structural and biochemical insights into the catalytic mechanisms of two insect chitin deacetylases of the carbohydrate esterase 4 family
por: Liu, Lin, et al.
Publicado: (2019)

Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism
por: Acquistapace, Isabella M., et al.
Publicado: (2020)

Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide
por: Heine, Christian L., et al.
Publicado: (2015)

Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
por: Söderholm, Annika, et al.
Publicado: (2020)

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
por: Egger, Sigrid, et al.
Publicado: (2012)

A comparative study of methylglyoxal metabolism in trypanosomatids
por: Greig, Neil, et al.
Publicado: (2009)

A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover
por: Loderer, Christoph, et al.
Publicado: (2017)

The Catalytic Aspartate Is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-like Inhibitor: A REFINED MECHANISM OF SERINE PROTEASE ACTION
por: Wahlgren, Weixiao Yuan, et al.
Publicado: (2011)

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression
por: Fisher, Nicholas, et al.
Publicado: (2012)

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION
por: Benson, Matthew A., et al.
Publicado: (2013)

Histidyl-tRNA Synthetase Urzymes: CLASS I AND II AMINOACYL tRNA SYNTHETASE URZYMES HAVE COMPARABLE CATALYTIC ACTIVITIES FOR COGNATE AMINO ACID ACTIVATION
por: Li, Li, et al.
Publicado: (2011)

Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target
por: Aroonsri, Aiyada, et al.
Publicado: (2019)

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog
por: Volkov, Oleg A, et al.
Publicado: (2016)

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
por: Jones, Deuan C, et al.
Publicado: (2012)

Allostery Wiring Map for Kinesin Energy Transduction and Its Evolution
por: Richard, Jessica, et al.
Publicado: (2016)

Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax
por: Njuguna, James T, et al.
Publicado: (2006)

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
por: Walsh, John G., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_dq9cvskjh1760l5g1b8ur2vm5l