The Polyphosphate Kinase Gene ppk2 Is Required for Mycobacterium tuberculosis Inorganic Polyphosphate Regulation and Virulence

The Mycobacterium tuberculosis gene Rv3232c/MT3329 (ppk2) encodes a class II polyphosphate kinase, which hydrolyzes inorganic polyphosphate (poly P) to synthesize GTP. We assessed the role of ppk2 in M. tuberculosis poly P regulation, antibiotic tolerance, and virulence. A ppk2-deficient mutant (ppk...

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Detalles Bibliográficos
Autores principales: Chuang, Yu-Min, Belchis, Deborah A., Karakousis, Petros C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663568/
https://www.ncbi.nlm.nih.gov/pubmed/23695835
http://dx.doi.org/10.1128/mBio.00039-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663568/
https://www.ncbi.nlm.nih.gov/pubmed/23695835
http://dx.doi.org/10.1128/mBio.00039-13

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