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Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D
BACKGROUND: Stalled replication forks at common fragile sites are a major cause of genomic instability. RecQ helicases, a highly conserved family of DNA-unwinding enzymes, are believed to ease ‘roadblocks’ that pose challenge to replication fork progression. Among the five known RecQ homologs in hum...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663727/ https://www.ncbi.nlm.nih.gov/pubmed/23601052 http://dx.doi.org/10.1186/1476-4598-12-29 |