PPAR-Alpha Agonists as Novel Antiepileptic Drugs: Preclinical Findings

Nicotinic acetylcholine receptors (nAChRs) are involved in seizure mechanisms. Hence, nocturnal frontal lobe epilepsy was the first idiopathic epilepsy linked with specific mutations in α4 or β2 nAChR subunit genes. These mutations confer gain of function to nAChRs by increasing sensitivity toward a...

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Detalles Bibliográficos
Autores principales: Puligheddu, Monica, Pillolla, Giuliano, Melis, Miriam, Lecca, Salvatore, Marrosu, Francesco, De Montis, Maria Graziella, Scheggi, Simona, Carta, Gianfranca, Murru, Elisabetta, Aroni, Sonia, Muntoni, Anna Lisa, Pistis, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664607/
https://www.ncbi.nlm.nih.gov/pubmed/23724059
http://dx.doi.org/10.1371/journal.pone.0064541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664607/
https://www.ncbi.nlm.nih.gov/pubmed/23724059
http://dx.doi.org/10.1371/journal.pone.0064541

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