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External pH modulates EAG superfamily K(+) channels through EAG-specific acidic residues in the voltage sensor

The Ether-a-go-go (EAG) superfamily of voltage-gated K(+) channels consists of three functionally distinct gene families (Eag, Elk, and Erg) encoding a diverse set of low-threshold K(+) currents that regulate excitability in neurons and muscle. Previous studies indicate that external acidification i...

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Detalles Bibliográficos
Autores principales: Kazmierczak, Marcin, Zhang, Xiaofei, Chen, Bihan, Mulkey, Daniel K., Shi, Yingtang, Wagner, Paul G., Pivaroff-Ward, Kendra, Sassic, Jessica K., Bayliss, Douglas A., Jegla, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664700/
https://www.ncbi.nlm.nih.gov/pubmed/23712551
http://dx.doi.org/10.1085/jgp.201210938