Developing BACE-1 inhibitors for FXS

Fragile X syndrome (FXS) is a debilitating genetic disorder with no cure and few therapeutic options. Excessive signaling through metabotropic glutamate receptor 5 in FXS leads to increased translation of numerous synaptic proteins and exaggerated long-term depression. Two of the overexpressed prote...

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Detalles Bibliográficos
Autores principales: Westmark, Cara J., Berry-Kravis, Elizabeth M., Ikonomidou, Chrysanthy, Yin, Jerry C. P., Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664772/
https://www.ncbi.nlm.nih.gov/pubmed/23754978
http://dx.doi.org/10.3389/fncel.2013.00077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664772/
https://www.ncbi.nlm.nih.gov/pubmed/23754978
http://dx.doi.org/10.3389/fncel.2013.00077

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