The monomeric GIY-YIG homing endonuclease I-BmoI uses a molecular anchor and a flexible tether to sequentially nick DNA

The GIY-YIG nuclease domain is found within protein scaffolds that participate in diverse cellular pathways and contains a single active site that hydrolyzes DNA by a one-metal ion mechanism. GIY-YIG homing endonucleases (GIY-HEs) are two-domain proteins with N-terminal GIY-YIG nuclease domains conn...

Descripción completa

Detalles Bibliográficos
Autores principales: Kleinstiver, Benjamin P., Wolfs, Jason M., Edgell, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664794/
https://www.ncbi.nlm.nih.gov/pubmed/23558745
http://dx.doi.org/10.1093/nar/gkt186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664794/
https://www.ncbi.nlm.nih.gov/pubmed/23558745
http://dx.doi.org/10.1093/nar/gkt186

Ejemplares similares