Structures of DNA duplexes containing O(6)-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations

N-nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation of O(6)-carboxymethylguanine (O(6)-CMG) in DNA. O(6)-CMG has been identified in DNA derived from human colon tissue, and its occurrence has been linked to diets high in red and processed me...

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Detalles Bibliográficos
Autores principales: Zhang, Fang, Tsunoda, Masaru, Suzuki, Kaoru, Kikuchi, Yuji, Wilkinson, Oliver, Millington, Christopher L., Margison, Geoffrey P., Williams, David M., Czarina Morishita, Ella, Takénaka, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664797/
https://www.ncbi.nlm.nih.gov/pubmed/23580550
http://dx.doi.org/10.1093/nar/gkt198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664797/
https://www.ncbi.nlm.nih.gov/pubmed/23580550
http://dx.doi.org/10.1093/nar/gkt198

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