Structures of DNA duplexes containing O(6)-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations

N-nitrosation of glycine and its derivatives generates potent alkylating agents that can lead to the formation of O(6)-carboxymethylguanine (O(6)-CMG) in DNA. O(6)-CMG has been identified in DNA derived from human colon tissue, and its occurrence has been linked to diets high in red and processed me...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Fang, Tsunoda, Masaru, Suzuki, Kaoru, Kikuchi, Yuji, Wilkinson, Oliver, Millington, Christopher L., Margison, Geoffrey P., Williams, David M., Czarina Morishita, Ella, Takénaka, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664797/
https://www.ncbi.nlm.nih.gov/pubmed/23580550
http://dx.doi.org/10.1093/nar/gkt198

Ejemplares similares

Ejemplares similares