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The role of DNA bending in type IIA topoisomerase function

Type IIA topoisomerases control DNA supercoiling and separate newly replicated chromosomes using a complex DNA strand cleavage and passage mechanism. Structural and biochemical studies have shown that these enzymes sharply bend DNA by as much as 150°; an invariant isoleucine, which has been seen str...

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Detalles Bibliográficos
Autores principales: Lee, Imsang, Dong, Ken C., Berger, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664819/
https://www.ncbi.nlm.nih.gov/pubmed/23580548
http://dx.doi.org/10.1093/nar/gkt238