High-Affinity PEGylated Polyacridine Peptide Polyplexes Mediate Potent In Vivo Gene Expression

PEGylated polyacridine peptides bind to plasmid DNA with high affinity to form unique polyplexes that possess a long circulatory half-life and are hydrodynamically (HD)-stimulated to produce efficient gene expression in the liver of mice. We previously demonstrated that (Acr-Lys)(6)-Cys-PEG(5kDa) st...

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Detalles Bibliográficos
Autores principales: Kizzire, Koby, Khargharia, Sanjib, Rice, Kevin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665005/
https://www.ncbi.nlm.nih.gov/pubmed/22786534
http://dx.doi.org/10.1038/gt.2012.47

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665005/
https://www.ncbi.nlm.nih.gov/pubmed/22786534
http://dx.doi.org/10.1038/gt.2012.47

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