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Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia
BACKGROUND: It is a great challenge of modern biology to determine the functional roles of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on complex phenotypes. Statistical and machine learning techniques establish correlations between genotype and phenotype, but may fail to infer the biolo...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665574/ https://www.ncbi.nlm.nih.gov/pubmed/23819581 http://dx.doi.org/10.1186/1471-2164-14-S3-S9 |