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Revealing selection in cancer using the predicted functional impact of cancer mutations. Application to nomination of cancer drivers
Every malignant tumor has a unique spectrum of genomic alterations including numerous protein mutations. There are also hundreds of personal germline variants to be taken into account. The combinatorial diversity of potential cancer-driving events limits the applicability of statistical methods to d...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665576/ https://www.ncbi.nlm.nih.gov/pubmed/23819556 http://dx.doi.org/10.1186/1471-2164-14-S3-S8 |