MSH3 Mismatch Repair Protein Regulates Sensitivity to Cytotoxic Drugs and a Histone Deacetylase Inhibitor in Human Colon Carcinoma Cells

BACKGROUND: MSH3 is a DNA mismatch repair (MMR) gene that undergoes frequent somatic mutation in colorectal cancers (CRCs) with MMR deficiency. MSH3, together with MSH2, forms the MutSβ heteroduplex that interacts with interstrand cross-links induced by drugs such as cisplatin. To date, the impact o...

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Detalles Bibliográficos
Autores principales: Park, Jae Myung, Huang, Shengbing, Tougeron, David, Sinicrope, Frank A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665625/
https://www.ncbi.nlm.nih.gov/pubmed/23724141
http://dx.doi.org/10.1371/journal.pone.0065369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665625/
https://www.ncbi.nlm.nih.gov/pubmed/23724141
http://dx.doi.org/10.1371/journal.pone.0065369

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