Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells

BACKGROUND: Multiple Myeloma (MM) is an incurable plasma cell malignancy residing within the bone marrow (BM). We aim to develop allogeneic Natural Killer (NK) cell immunotherapy for MM. As the BM contains hypoxic regions and the tumor environment can be immunosuppressive, we hypothesized that hypox...

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Detalles Bibliográficos
Autores principales: Sarkar, Subhashis, Germeraad, Wilfred T. V., Rouschop, Kasper M. A., Steeghs, Elisabeth M. P., van Gelder, Michel, Bos, Gerard M. J., Wieten, Lotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665801/
https://www.ncbi.nlm.nih.gov/pubmed/23724099
http://dx.doi.org/10.1371/journal.pone.0064835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665801/
https://www.ncbi.nlm.nih.gov/pubmed/23724099
http://dx.doi.org/10.1371/journal.pone.0064835

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