Association of a Genetic Variation in a miR-191 Binding Site in MDM4 with Risk of Esophageal Squamous Cell Carcinoma

As an oncoprotein, MDM4 plays a key part in P53 tumor suppressor pathway through negatively regulating P53 function. It has been reported that an rs4245739 A>C polymorphism locating in the MDM4 3′-untranslated region creates a miR-191 target site and results in decreased MDM4 expression. Therefor...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Liqing, Zhang, Xiaojiao, Li, Ziqiang, Zhou, Changchun, Li, Meng, Tang, Xiaohu, Lu, Chao, Li, Helou, Yuan, Qipeng, Yang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665831/
https://www.ncbi.nlm.nih.gov/pubmed/23724042
http://dx.doi.org/10.1371/journal.pone.0064331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665831/
https://www.ncbi.nlm.nih.gov/pubmed/23724042
http://dx.doi.org/10.1371/journal.pone.0064331

Ejemplares similares