Cargando…

Evidence for a Role of LPGAT1 in Influencing BMI and Percent Body Fat in Native Americans

OBJECTIVE: A genome-wide association study (GWAS) was recently completed in 1120 Pima Indians to identify loci that influence BMI. Among the top 100 signals were three variants that mapped within the lysophosphatidylglycerol acyltransferase 1 (LPGAT1) gene. LPGAT1 belongs to a large family of acyltr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Traurig, Michael T, Orczewska, Julieanna I, Ortiz, Daniel J, Bian, Li, Marinelarena, Alejandra M, Kobes, Sayuko, Malhotra, Alka, Hanson, Robert L, Mason, Clint C, Knowler, William C, Bogardus, Clifton, Baier, Leslie J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2013
Materias:	Epidemiology/Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666094/ https://www.ncbi.nlm.nih.gov/pubmed/23505186 http://dx.doi.org/10.1002/oby.20243

Ejemplares similares

MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation
por: Bian, Li, et al.
Publicado: (2013)

Variants in the LEPR gene are nominally associated with higher BMI and lower 24 hour energy expenditure in Pima Indians
por: Traurig, Michael, et al.
Publicado: (2012)

Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians
por: Traurig, Michael, et al.
Publicado: (2009)

Assessing Accuracy of Genotype Imputation in American Indians
por: Malhotra, Alka, et al.
Publicado: (2014)

Variants in ASK1 Are Associated With Skeletal Muscle ASK1 Expression, In Vivo Insulin Resistance, and Type 2 Diabetes in Pima Indians
por: Bian, Li, et al.
Publicado: (2010)

Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant
por: Krakoff, Jonathan, et al.
Publicado: (2008)

Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity
por: Day, Samantha E., et al.
Publicado: (2022)

Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians
por: Rong, Rong, et al.
Publicado: (2009)

Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex
por: Nair, Anup K., et al.
Publicado: (2018)

Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants With Type 2 Diabetes in American Indians
por: Hanson, Robert L., et al.
Publicado: (2013)

Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes
por: Muller, Yunhua L., et al.
Publicado: (2013)

Whole Exome Sequencing Identifies Variation in CYB5A and RNF10 Associated with Adiposity and Type 2 Diabetes
por: Huang, Ke, et al.
Publicado: (2013)

PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians
por: Ma, Lijun, et al.
Publicado: (2008)

Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure
por: Muller, Yunhua L., et al.
Publicado: (2014)

Assessing FOXO1A as a Potential Susceptibility Locus for Type 2 Diabetes and Obesity in American Indians
por: Muller, Yunhua L., et al.
Publicado: (2015)

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes
por: Baier, Leslie J., et al.
Publicado: (2015)

A Genome-Wide Association Study in American Indians Implicates DNER as a Susceptibility Locus for Type 2 Diabetes
por: Hanson, Robert L., et al.
Publicado: (2014)

Assessing the Role of 98 Established Loci for Body Mass Index in American Indians
por: Muller, Yunhua L., et al.
Publicado: (2019)

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children
por: Muller, Yunhua L., et al.
Publicado: (2014)

Evaluation of A2BP1 as an Obesity Gene
por: Ma, Lijun, et al.
Publicado: (2010)

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians
por: Piaggi, Paolo, et al.
Publicado: (2017)

Exome Sequencing of 21 Bardet‐Biedl Syndrome (BBS) Genes to Identify Obesity Variants in 6,851 American Indians
por: Day, Samantha E., et al.
Publicado: (2021)

Bimodal distribution of RNA expression levels in human skeletal muscle tissue
por: Mason, Clinton C, et al.
Publicado: (2011)

LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling
por: Xu, Yang, et al.
Publicado: (2022)

Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish
por: Muller, Yunhua L., et al.
Publicado: (2010)

The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population
por: Wedekind, Lauren E., et al.
Publicado: (2023)

The enriched home environment and dietary intake are related to percent overBMI in children
por: Epstein, Leonard H., et al.
Publicado: (2021)

LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles
por: Sato, Tomoki, et al.
Publicado: (2023)

Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians
por: Nair, Anup K., et al.
Publicado: (2022)

Glycemia affects glomerular filtration rate in people with type 2 diabetes
por: Weil, E. Jennifer, et al.
Publicado: (2019)

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians
por: Thearle, Marie S., et al.
Publicado: (2012)

Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish
por: Shibata, Takeaki, et al.
Publicado: (2022)

Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP
por: Nair, Anup K., et al.
Publicado: (2014)

Role of Established Type 2 Diabetes–Susceptibility Genetic Variants in a High Prevalence American Indian Population
por: Hanson, Robert L., et al.
Publicado: (2015)

Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat, and Leptin
por: Shah, Nirav R., et al.
Publicado: (2012)

Body Weight, BMI, Percent Fat and Associations with Mortality and Incident Mobility Limitation in Older Men
por: Cawthon, Peggy M., et al.
Publicado: (2021)

Consumption of takeaway and delivery meals is associated with increased BMI and percent fat among UK Biobank participants
por: Albalawi, Ahmad A, et al.
Publicado: (2022)

The tree of one percent
por: Dagan, Tal, et al.
Publicado: (2006)

The One-Percent Edge
por: Solovic, Susan
Publicado: (2018)

Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion
por: Chang, Douglas C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hgoan10896pn09k06ejgta4kve