Sterol C-22 Desaturase ERG5 Mediates the Sensitivity to Antifungal Azoles in Neurospora crassa and Fusarium verticillioides

Antifungal azoles inhibit ergosterol biosynthesis by interfering with lanosterol 14α-demethylase. In this study, seven upregulated and four downregulated ergosterol biosynthesis genes in response to ketoconazole treatment were identified in Neurospora crassa. Azole sensitivity test of knockout mutan...

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Detalles Bibliográficos
Autores principales: Sun, Xianyun, Wang, Wenzhao, Wang, Kangji, Yu, Xinxu, Liu, Jie, Zhou, Fucai, Xie, Baogui, Li, Shaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666115/
https://www.ncbi.nlm.nih.gov/pubmed/23755044
http://dx.doi.org/10.3389/fmicb.2013.00127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666115/
https://www.ncbi.nlm.nih.gov/pubmed/23755044
http://dx.doi.org/10.3389/fmicb.2013.00127

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