Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

Decoquinate (DQ) is highly effective at killing malaria parasites in vitro; however, it is extremely insoluble in water. In this study, solid dispersion method was used for DQ formulation which created a suitable physical form of DQ in aqueous phase for particle manipulation. Among many polymers and...

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Detalles Bibliográficos
Autores principales: Wang, Hongxing, Li, Qigui, Reyes, Sean, Zhang, Jing, Xie, Lisa, Melendez, Victor, Hickman, Mark, Kozar, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666196/
https://www.ncbi.nlm.nih.gov/pubmed/23766925
http://dx.doi.org/10.1155/2013/769234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666196/
https://www.ncbi.nlm.nih.gov/pubmed/23766925
http://dx.doi.org/10.1155/2013/769234

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