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Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

Decoquinate (DQ) is highly effective at killing malaria parasites in vitro; however, it is extremely insoluble in water. In this study, solid dispersion method was used for DQ formulation which created a suitable physical form of DQ in aqueous phase for particle manipulation. Among many polymers and...

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Detalles Bibliográficos
Autores principales:	Wang, Hongxing, Li, Qigui, Reyes, Sean, Zhang, Jing, Xie, Lisa, Melendez, Victor, Hickman, Mark, Kozar, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666196/ https://www.ncbi.nlm.nih.gov/pubmed/23766925 http://dx.doi.org/10.1155/2013/769234

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